Association between Polymorphisms in Glutathione Peroxidase and Selenoprotein P Genes, Glutathione Peroxidase Activity, HRT Use and Breast Cancer Risk

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Association between Polymorphisms in Glutathione Peroxidase and Selenoprotein P Genes, Glutathione Peroxidase Activity, HRT Use and Breast Cancer Risk

Breast cancer (BC) is one of the most common cancers in women. Evidence suggests that genetic variation in antioxidant enzymes could influence BC risk, but to date the relationship between selenoproteins and BC risk remains unclear. In this report, a study population including 975 Danish cases and 975 controls matched for age and hormone replacement therapy (HRT) use was genotyped for five func...

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No association between glutathione peroxidase Pro198Leu polymorphism and breast cancer risk.

Department of Epidemiology, Roswell Park Cancer Institute, Buffalo, New York; Department of Epidemiology, School of Public Health, University of North Carolina, Chapel Hill, North Carolina; Departments of Environmental Health Sciences and Epidemiology, Mailman School of Public Health; Department of Medicine, College of Physicians and Surgeons, Columbia University, New York, New York; and Depart...

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ژورنال

عنوان ژورنال: PLoS ONE

سال: 2013

ISSN: 1932-6203

DOI: 10.1371/journal.pone.0073316